About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkd1l1rks
rikishi
MGI:4948351
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pkd1l1rks/Pkd1l1rks C3H.B6-Pkd1l1rks MGI:4948352
ht2
 		Pkd1l1rks/Pkd1l1+ C3H.B6-Pkd1l1rks MGI:4948353
cx3
 		Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+ 		C3.Cg-Pkd2lrm4 Pkd1l1rks MGI:4948354


Genotype
MGI:4948352
hm1
Allelic
Composition		 Pkd1l1rks/Pkd1l1rks
Genetic
Background		 C3H.B6-Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (1 available); any Pkd1l1 mutation (156 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:170490 )
• most embryos die by E15.5 and the few remaining embryos are developmentally delayed and close to death

embryo
embryo phenotype ( J:170490 )
N
• embryonic node cilia motion appears normal
abnormal direction of embryo turning ( J:170490 )
• at E9.5 embryos display normal, inverted or indifferent turning
abnormal left-right axis patterning ( J:170490 )
• expression analysis detects defect in left-right asymmetry of the lateral plate mesoderm
embryonic growth arrest ( J:170490 )
• arrest around E14.5
embryonic growth retardation ( J:170490 )
• the few embryos alive at E15.5 are developmentally delayed

homeostasis/metabolism
edema ( J:170490 )
• in 25 of 28 embryos at E13.5 - E14.5

growth/size/body
right-sided stomach ( J:170490 )
• in some embryos at E13.5 - E14.5
embryonic growth retardation ( J:170490 )
• the few embryos alive at E15.5 are developmentally delayed
right pulmonary isomerism ( J:170490 )
• seen in all embryos

cardiovascular system
dextrocardia ( J:170490 )
• in some embryos at E13.5 - E14.5

digestive/alimentary system
right-sided stomach ( J:170490 )
• in some embryos at E13.5 - E14.5

respiratory system
right pulmonary isomerism ( J:170490 )
• seen in all embryos




Genotype
MGI:4948353
ht2
Allelic
Composition		 Pkd1l1rks/Pkd1l1+
Genetic
Background		 C3H.B6-Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (1 available); any Pkd1l1 mutation (156 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:170490 )
N
• unlike in mice heterozygous for null alleles of Pkd1 or Pkd2, no kidney cysts are detected in mice at up to 18 months of age




Genotype
MGI:4948354
cx3
Allelic
Composition		 Pkd1l1rks/Pkd1l1+
Pkd2lrm4/Pkd2+
Genetic
Background		 C3.Cg-Pkd2lrm4 Pkd1l1rks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1l1rks mutation (1 available); any Pkd1l1 mutation (156 available)
Pkd2lrm4 mutation (1 available); any Pkd2 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:170490 )
• no abnormal kidney, cardiac or situs pathology is detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory