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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map1stm1.1Lliu
targeted mutation 1.1, Leyuan Liu
MGI:4948361
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map1stm1.1Lliu/Map1stm1.1Lliu involves: 129S4/SvJaeSor * C57BL/6 MGI:4948442
cx2
 		Map1stm1.1Lliu/Map1stm1.1Lliu
Tg(CAG-EGFP/Map1lc3b)53Nmz/0 		involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj MGI:4948445


Genotype
MGI:4948442
hm1
Allelic
Composition		 Map1stm1.1Lliu/Map1stm1.1Lliu
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1stm1.1Lliu mutation (0 available); any Map1s mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal autophagosome formation ( J:170757 )
• cells exhibit defective autophagosome biogenesis compared with cells from wild-type mice

reproductive system
reproductive system phenotype ( J:170757 )
N
• mice exhibit normal reproduction

cardiovascular system
abnormal myocardial fiber morphology ( J:170757 )
• cardiomyocytes in neonates and adult exhibit a 3-fold increase in dysfunctional mitochondria compared with wild-type mice

cellular
abnormal autophagosome formation ( J:170757 )
• cells exhibit defective autophagosome biogenesis compared with cells from wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:170757 )
N
• mice exhibit normal behavior

muscle
abnormal myocardial fiber morphology ( J:170757 )
• cardiomyocytes in neonates and adult exhibit a 3-fold increase in dysfunctional mitochondria compared with wild-type mice




Genotype
MGI:4948445
cx2
Allelic
Composition		 Map1stm1.1Lliu/Map1stm1.1Lliu
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1stm1.1Lliu mutation (0 available); any Map1s mutation (37 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:170757 )
• starved neonates survival time is half that of similarly treated wild-type mice

cellular
abnormal autophagy ( J:170757 )
• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice

homeostasis/metabolism
abnormal autophagy ( J:170757 )
• heart and liver tissues from pups under nutritive stress exhibit early accumulation of autophagosomes associated with impaired autophagosomal degradation compared with tissues form wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory