Phenotypes associated with this allele

• Allele Symbol: Rr117^tm1.1Dje
• Allele Name: targeted mutation 1.1, Douglas J Epstein
• Allele ID: MGI:4948508
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr117^tm1.1Dje/Rr117^tm1.1Dje	involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N	MGI:4948510
cx2	Rr117^tm1.1Dje/Rr117^+ Shh^tm1Amc/Shh^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4948512

Genotype
MGI:4948510

hm1

• Allelic Composition: Rr117^tm1.1Dje/Rr117^tm1.1Dje
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:170540 )

N • no gross morphological defects in the brain

Genotype
MGI:4948512

cx2

• Allelic Composition: Rr117^tm1.1Dje/Rr117⁺; Shh^tm1Amc/Shh⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

mortality/aging

postnatal lethality, incomplete penetrance ( J:170540 )

• 80% of mice fail to gain weight and die by 7 days of age

• 20% survive to adulthood

growth/size/body

slow postnatal weight gain ( J:170540 )

• normal weight at birth

• 80% fail to gain weight after birth and die by 7 days of age

• the 20% who survive remain remain small, 33% of normal weight

behavior/neurological

behavior/neurological phenotype ( J:170540 )

N • normal suckling response

N • dead pups often have milk in their stomach

N • well coordinated motor control

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:170540 )

N • normal blood glucose