About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Keap1tm1.1Sbis
targeted mutation 1.1, Shyam Biswal
MGI:4948838
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Keap1tm1.1Sbis/Keap1tm1.1Sbis
Tg(Scgb1a1-cre)1Grau/0 		involves: C57BL/6J MGI:4948839


Genotype
MGI:4948839
cn1
Allelic
Composition		 Keap1tm1.1Sbis/Keap1tm1.1Sbis
Tg(Scgb1a1-cre)1Grau/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keap1tm1.1Sbis mutation (1 available); any Keap1 mutation (36 available)
Tg(Scgb1a1-cre)1Grau mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung epithelium morphology ( J:170960 )
• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells
abnormal club cell morphology ( J:170960 )
• Clara cells exposed to hydrogen peroxide exhibit lower levels of reactive oxygen species compared with similarly-treated wild-type cells

homeostasis/metabolism
decreased susceptibility to injury ( J:170960 )
• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory