All Phenotypes Egln1<tm1.1Brei> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egln1^tm1.1Brei/Egln1^tm1.1Brei Myl2^tm1(cre)Krc/Myl2⁺	B6.Cg-Myl2^tm1(cre)Krc Egln1^tm1.1Brei	MGI:4948937
cn2	Egln1^tm1.1Brei/Egln1^tm1.1Brei Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(CD68-icre)1Bwlx/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5568401
cn3	Egln1^tm1.1Brei/Egln1^tm1.1Brei Egln3^tm2Fong/Egln3^tm2Fong Tg(CD68-icre)1Bwlx/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5568402
cn4	Egln1^tm1.1Brei/Egln1^tm1.1Brei Epas1^tm1Mcs/Epas1^tm1Mcs Tg(CD68-icre)1Bwlx/0	involves: 129X1/SvJ * C57BL/6	MGI:5568400
cn5	Egln1^tm1.1Brei/Egln1^tm1.1Brei Tg(CD68-icre)1Bwlx/0	involves: C57BL/6	MGI:5568399

Allelic Composition	Egln1^tm1.1Brei/Egln1^tm1.1Brei Myl2^tm1(cre)Krc/Myl2⁺
Genetic Background	B6.Cg-Myl2^tm1(cre)Krc Egln1^tm1.1Brei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm1.1Brei mutation (0 available); any Egln1 mutation (22 available)
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:170943 )

N	• mice exhibit normal cardiac response to increased afterload

abnormal coronary vessel morphology ( J:170943 )

• capillary area is increased compared to in wild-type hearts

• however, capillary number is normal

abnormal response to cardiac infarction ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk, area of necrosis, apoptosis, and reduced decrease in fractional shortening compared with similarly treated wild-type mice

decreased myocardial infarct size ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk and area of necrosis compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:170943 )

decreased myocardial infarct size ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk and area of necrosis compared with similarly treated wild-type mice

muscle

decreased cardiomyocyte apoptosis ( J:170943 )

• following ligation of the left anterior descending artery

cellular

decreased cardiomyocyte apoptosis ( J:170943 )

• following ligation of the left anterior descending artery

Allelic Composition	Egln1^tm1.1Brei/Egln1^tm1.1Brei Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(CD68-icre)1Bwlx/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm1.1Brei mutation (0 available); any Egln1 mutation (22 available)
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(CD68-icre)1Bwlx mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:194598 )

• mice start dying suddenly at 5 weeks with 95% mortality by 16 weeks (mean survival time = 11 weeks)

hematopoietic system

hematopoietic system phenotype ( J:194598 )

N	• no cardiovascular complications or thromboses are observed

increased hematocrit ( J:194598 )

• not different from CD68cre/Phd2^fl mice

craniofacial

domed cranium ( J:194598 )

• 3/16 mice show this

nervous system

hydrocephaly ( J:194598 )

• mice with domed skulls show dramatic hydrocephalus

skeleton

domed cranium ( J:194598 )

• 3/16 mice show this

Allelic Composition	Egln1^tm1.1Brei/Egln1^tm1.1Brei Egln3^tm2Fong/Egln3^tm2Fong Tg(CD68-icre)1Bwlx/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm1.1Brei mutation (0 available); any Egln1 mutation (22 available)
Egln3^tm2Fong mutation (1 available); any Egln3 mutation (26 available)
Tg(CD68-icre)1Bwlx mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

polycythemia ( J:194598 )

• mice display severe erythrocytosis

mortality/aging

neonatal lethality ( J:194598 )

• animals start dying shortly after birth

Allelic Composition	Egln1^tm1.1Brei/Egln1^tm1.1Brei Epas1^tm1Mcs/Epas1^tm1Mcs Tg(CD68-icre)1Bwlx/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm1.1Brei mutation (0 available); any Egln1 mutation (22 available)
Epas1^tm1Mcs mutation (1 available); any Epas1 mutation (66 available)
Tg(CD68-icre)1Bwlx mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:194598 )

N	• no premature death is observed

hematopoietic system

hematopoietic system phenotype ( J:194598 )

N	• erythropoiesis phenotype seen in Phd2 single mutants is absent from double mutants

decreased hematocrit ( J:194598 )

• HCT is lower than wild type

decreased hemoglobin content ( J:194598 )

• lower than in wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:194598 )

N	• no premature death is observed; some erythrocytotic mutants live for more than 20 months with no observed decrease in hematocrit

growth/size/body

postnatal growth retardation ( J:194598 )

• severe growth retardation occurs in conjunction with skin redness until adulthood

enlarged spleen ( J:194598 )

increased spleen weight ( J:194598 )

hematopoietic system

hematopoietic system phenotype ( J:194598 )

N	• F4/80+ macrophages and neutrophils are not significantly different from wild type, but red pulp macrophages are highly induced in the spleen

abnormal megakaryocyte progenitor cell morphology ( J:194598 )

• megakaryocyte-erythroid progenitors (MEPs) are significantly induced (>2.5 fold) in the spleen, but not in bone marrow

increased erythroblast number ( J:194598 )

• splenic CD71+ve/Ter119+ve erythroblasts are increase >10-fold with mild increase in bone marrow

polycythemia ( J:194598 )

• results in splenomegaly

increased hematocrit ( J:194598 )

• increases with age to >85% in some animals

abnormal nucleated erythrocyte cell number ( J:194598 )

• splenomegaly occurs with increase in nucleated cells

thrombocytopenia ( J:194598 )

• significantly decreased

abnormal lymphocyte cell number ( J:194598 )

• fraction of B and T cells in spleen is significantly decreased but in lymph nodes these numbers are increased

abnormal spleen morphology ( J:194598 )

• splenomegaly occurs with loss of splenic architecture

enlarged spleen ( J:194598 )

increased spleen weight ( J:194598 )

cardiovascular system

abnormal blood viscosity ( J:194598 )

• viscosity is increased but no differences in heart rate, blood pressure or cardiac hypertrophy is observed

hypervolemia ( J:194598 )

• blood volume increased by 65%

immune system

abnormal lymphocyte cell number ( J:194598 )

• fraction of B and T cells in spleen is significantly decreased but in lymph nodes these numbers are increased

abnormal spleen morphology ( J:194598 )

• splenomegaly occurs with loss of splenic architecture

enlarged spleen ( J:194598 )

increased spleen weight ( J:194598 )

integument

reddish skin ( J:194598 )

• redness of paws and snouts is observed by 4 weeks of age

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