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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Parp3tm1.2Ics
targeted mutation 1.2, Mouse Clinical Institute
MGI:4948941
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Parp3tm1.2Ics/Parp3tm1.2Ics involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948944
cx2
 		Parp1tm1Jmdm/Parp1tm1Jmdm
Parp3tm1.2Ics/Parp3tm1.2Ics 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948946


Genotype
MGI:4948944
hm1
Allelic
Composition		 Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp3tm1.2Ics mutation (1 available); any Parp3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:170941 )
N
• mice exhibit normal Mendelian frequency and survival postirradiation




Genotype
MGI:4948946
cx2
Allelic
Composition		 Parp1tm1Jmdm/Parp1tm1Jmdm
Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp1tm1Jmdm mutation (1 available); any Parp1 mutation (66 available)
Parp3tm1.2Ics mutation (1 available); any Parp3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:170941 )
• 126 days postirradiation, only 4 of 11 mice survive compared with 7 of 9 Parp1tm1Jmdm homozygotes

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:170941 )
• 126 days postirradiation, only 4 of 11 mice survive compared with 7 of 9 Parp1tm1Jmdm homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory