Phenotypes associated with this allele

• Allele Symbol: Map2k7^tm1.1Twad
• Allele Name: targeted mutation 1.1, Teiji Wada
• Allele ID: MGI:4948950
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k7^tm1.1Twad/Map2k7^tm1.1Twad	B6.Cg-Map2k7^tm1.1Twad	MGI:4948959
cn2	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	MGI:4948962
cn3	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4948964
cn4	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(Trp53)bSrn/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA	MGI:4948965
cn5	Map2k7^tm1.1Twad/Map2k7^tm1.1Twad Tg(KRT5-cre)1Tak/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:4948960
cn6	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N	MGI:4948967
cn7	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4948966

Genotype
MGI:4948959

hm1

• Allelic Composition: Map2k7^tm1.1Twad/Map2k7^tm1.1Twad
• Genetic Background: B6.Cg-Map2k7^tm1.1Twad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:170904 )

• mice are viable and fertile with no detectable phenotype

Genotype
MGI:4948962

cn2

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Map2k7^tm1.1Twad/Map2k7^tm1.2Twad
• Genetic Background: B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad

mortality/aging

premature death ( J:170904 )

neoplasm

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

cellular

abnormal DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

homeostasis/metabolism

abnormal DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

respiratory system

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

Genotype
MGI:4948964

cn3

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Map2k7^tm1.1Twad/Map2k7^tm1.2Twad; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

neoplasm

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

• however, tumorigenesis is the same as in Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

increased lung adenocarcinoma incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

respiratory system

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

• however, tumorigenesis is the same as in Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

increased lung adenocarcinoma incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

Genotype
MGI:4948965

cn4

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Map2k7^tm1.1Twad/Map2k7^tm1.2Twad; Tg(Trp53)bSrn/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

neoplasm

neoplasm ( J:170904 )

N • following adenovirus cre infection, mice exhibit the same tumor burden as in control mice

Genotype
MGI:4948960

cn5

• Allelic Composition: Map2k7^tm1.1Twad/Map2k7^tm1.1Twad; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

vision/eye

eyelids open at birth ( J:170904 )

Genotype
MGI:4948967

cn6

• Allelic Composition: Map2k7^tm1.1Twad/Map2k7^tm1.2Twad; Tg(MMTV-cre)4Mam/0; Tg(MMTV-Erbb2)1Pv/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

mortality/aging

premature death ( J:170904 )

• compared with control mice

neoplasm

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

integument

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

♀

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

♀

Genotype
MGI:4948966

cn7

• Allelic Composition: Map2k7^tm1.1Twad/Map2k7^tm1.2Twad; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

reproductive system

reproductive system phenotype ( J:170904 )

N • mice exhibit normal mammary gland formation throughout puberty