About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Trp53)bSrn
transgene insertion b, Manuel Serrano
MGI:4948957
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(Trp53)bSrn/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4948965
tg2
 		Tg(Trp53)bSrn/0 involves: C57BL/6 * CBA MGI:5751689


Genotype
MGI:4948965
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(Trp53)bSrn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Map2k7tm1.1Twad mutation (0 available); any Map2k7 mutation (20 available)
Map2k7tm1.2Twad mutation (0 available); any Map2k7 mutation (20 available)
Tg(Trp53)bSrn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:170904 )
N
• following adenovirus cre infection, mice exhibit the same tumor burden as in control mice




Genotype
MGI:5751689
tg2
Allelic
Composition		 Tg(Trp53)bSrn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53)bSrn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus and spleen following whole body irradiation
• increase is greater than in Tg(Trp53)1Srn mice

endocrine/exocrine glands
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus and spleen following whole body irradiation
• increase is greater than in Tg(Trp53)1Srn mice

hematopoietic system
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus and spleen following whole body irradiation
• increase is greater than in Tg(Trp53)1Srn mice

immune system
increased thymocyte apoptosis ( J:80311 )
• increased induction of apoptosis in thymus and spleen following whole body irradiation
• increase is greater than in Tg(Trp53)1Srn mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory