Analysis Tools
homeostasis/metabolism
| N |
• young adult mice exhibit normal body temperature regulation
• at 18 weeks, mice exhibit normal glucose and insulin tolerance
• mice fed a high fat diet and maintained at 4 or 28 degree Celsius exhibit normal respiratory exchange ratio
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• running capacity is half that of wild-type mice
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• at 20 degrees Celsius, metabolic efficiency is reduced 1.45-fold compared to in wild-type mice
• at 28 degrees Celsius, metabolic efficiency is reduced 1.35-fold compared to in wild-type mice
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• when fed a high-fat diet and maintained at 20 or 28 degrees Celsius
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• when fed a high-fat diet and maintained at 4, 20, or 28 degrees Celsius
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growth/size/body
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• when fed standard chow after weaning
• when fed a high-fat diet and maintained at 20 or 28 degrees Celsius on a high-fat diet
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• when fed a high-fat diet and maintained at 20 or 28 degrees Celsius
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• when fed a high-fat diet and maintained at 20 or 28 degrees Celsius
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adipose tissue
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• at 20 degrees Celsius, mice fed a high-fat diet exhibit lower fat mass gain compared with similarly treated wild-type mice
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• when fed standard chow after weaning
• when fed a high-fat diet and maintained at 20 or 28 degrees Celsius on a high-fat diet
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behavior/neurological
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• when fed a high fat diet and maintained at 28 degrees Celsius
• however, food intake is normal when maintained at 20 degrees Celsius
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• running capacity is half that of wild-type mice
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cellular
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• fibroblasts exhibit reduced calcium ion flux and ATP content compared with wild-type cells
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muscle
| N |
• mice exhibit a normal ratio of muscle fiber types
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