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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhebtm1.1Yelg
targeted mutation 1.1, Ype Elgersma
MGI:4949062
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhebtm1.1Yelg/Rhebtm1.1Yelg B6.129P2-Rhebtm1.1Yelg MGI:4949083
cx2
Rhebtm1.1Yelg/Rheb+
Tsc1tm1Chdl/Tsc1tm1Chdl
B6.129P2-Tsc1tm1Chdl Rhebtm1.1Yelg MGI:4949084


Genotype
MGI:4949083
hm1
Allelic
Composition
Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic
Background
B6.129P2-Rhebtm1.1Yelg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebtm1.1Yelg mutation (0 available); any Rheb mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around E12.5 probably due to circulatory failure secondary to poor heart development

cardiovascular system
• pointing toward cardiorrhexis
• in 2 of 3 mice

cellular
• embryos exhibit increased patches of apoptosis, particularly in the liver, unlike wild-type mice
• mouse embryonic fibroblasts hardly proliferate compared with wild-type cells

embryo
• embryos exhibit increased patches of apoptosis, particularly in the liver, unlike wild-type mice
• at E10.5 and E12.5
• in embryos

homeostasis/metabolism
• in 2 of 3 mice

growth/size/body
• at E10.5 and E12.5




Genotype
MGI:4949084
cx2
Allelic
Composition
Rhebtm1.1Yelg/Rheb+
Tsc1tm1Chdl/Tsc1tm1Chdl
Genetic
Background
B6.129P2-Tsc1tm1Chdl Rhebtm1.1Yelg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebtm1.1Yelg mutation (0 available); any Rheb mutation (26 available)
Tsc1tm1Chdl mutation (0 available); any Tsc1 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between E15.5 and birth unlike Tsc1tm1Chdl heterozygotes which die between E10.5 and E13.5

growth/size/body

cellular

embryo





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory