Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mir9-2tm1Sia targeted mutation 1, Shinichi Aizawa MGI:4949252 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die within 1 month of birth
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| N |
• no apparent defects in neurogenesis in the pallium or subpallium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die within 1 week after birth
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• barely any interneurons are present in the pallium
• however, interneurons appear to be normally specified in the medial ganglionic eminences and in the rostral migratory stream to the olfactory bulb
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• nearly absent
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• the basolateral amygdala is absent
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• in the ventral telencephalon corticofugal axons poorly innervate the internal capsule, thalmocortical axons are nearly lost before reaching the internal capsule, and the majority of fibers abnormally descend into the hypothalamus
• corridor neurons originating in the lateral ganglionic eminences are expanded and dispersed
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• increase in cell proliferation in the cortices at E12.5
• the pallial-subpallial boundary is shifted dorsally
• the glial palisade of the pallial-subpallial boundary is aberrant and less fasciculated
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• reduced at E18.5
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• greatly reduced numbers in the marginal zone at E12.5 and E13.5
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• marked reduction of the cortical layers and ventricular zone
• decrease in the numbers of early differentiated Tuj1-, Neurod1- or Tbr1-positive neurons in the preplate at E12.5
• increase in cell proliferation at E13.5
• decrease in the number of cells reentering the cell cycle at E16.5 suggesting a depletion of the progenitor pool
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• the proliferating zone is hyperplastic and differentiated structures are reduced
• hyperplastic and the cell-dense proliferating field is expanded into the deep differentiating field at E15.5
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• reduced at E18.5
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• small cerebral hemispheres
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• each cortical projection is greatly reduced
• barely any interneurons are present in the pallium
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• at E18.5 calretinin-positive layer I, Cux1-positive layer II/III, Satb2-positive layer II-IV, Rorb-positive layer IV, Er81-positive layer V, and calretinin-positive subplate are reduced
• however, the Foxp2- or Tbr1-positive layer VI is almost normal
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• marked reduction of the cortical layers and ventricular zone
• hypoplastic at P1
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• increase in cell proliferation at E13.5
• thinner with fewer BrdU positive cells in S phase at E15.5
• the Islet1-positive lateral ganglionic eminence subventricular zone is expanded while the differentiating area is reduced at E15.5
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• the Islet1-positive lateral ganglionic eminence subventricular zone is expanded while the differentiating area is reduced at E15.5
• at E15.5, but not at E12.5, the number of proliferating cells is increased particularly in the deeper area
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• axons of commissural neurons labeled by L1 (corpus callosum, anterior commissure, and fornix/hippocampal commissure) are poorly formed
• corticofugal axons are thin in the pallium
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• severe growth retardation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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