Phenotypes associated with this allele

• Allele Symbol: Tg(Hhex-EGFP)#Rbe
• Allele Name: transgene insertion, Rosa S P Beddington
• Allele ID: MGI:4949257
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lefty1^tm1Hmd/Lefty1^tm1Hmd Tg(Hhex-EGFP)#Rbe/0	involves: 129P2/OlaHsd * C57BL/6 * CBA/J	MGI:4949262
cx2	Pign^m1Nisw/Pign^m1Nisw Tg(Hhex-EGFP)#Rbe/0	involves: 129S1/SvImJ * C3H/HeJ * CBA/J * C57BL/6 * C57BL/6J	MGI:6361208
cx3	Pgap1^m1Nisw/Pgap1^m1Nisw Tg(Hhex-EGFP)#Rbe/0	involves: C57BL/6 * C57BL/6J * CBA/J	MGI:6361209
cx4	Pold1^tyrn/Pold1^tyrn Tg(Hhex-EGFP)#Rbe/0	involves: C57BL/6 * C57BL/6J * CBA/J	MGI:7467523
cx5	Rac1^tm2Tyb/Rac1^tm2Tyb Tg(Hhex-EGFP)#Rbe/0	mixed	MGI:5050122

Genotype
MGI:4949262

cx1

• Allelic Composition: Lefty1^tm1Hmd/Lefty1^tm1Hmd; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:170681 )

• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice

• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

cellular

abnormal anterior visceral endoderm cell migration ( J:170681 )

• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice

• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

Genotype
MGI:6361208

cx2

• Allelic Composition: Pign^m1Nisw/Pign^m1Nisw; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: involves: 129S1/SvImJ * C3H/HeJ * CBA/J * C57BL/6 * C57BL/6J

cellular

abnormal anterior visceral endoderm cell migration ( J:187360 )

embryo

abnormal anterior visceral endoderm cell migration ( J:187360 )

abnormal anterior definitive endoderm morphology ( J:187360 )

• E7.5 embryos exhibit a modest displacement of the anterior definitive endoderm towards the distal tip compared to wild-type embryos

abnormal anterior visceral endoderm morphology ( J:187360 )

• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with a displacement at the distal tip

abnormal distal visceral endoderm morphology ( J:187360 )

• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with a displacement at the distal tip

Genotype
MGI:6361209

cx3

• Allelic Composition: Pgap1^m1Nisw/Pgap1^m1Nisw; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

cellular

abnormal anterior visceral endoderm cell migration ( J:187360 )

embryo

abnormal anterior visceral endoderm cell migration ( J:187360 )

abnormal anterior definitive endoderm morphology ( J:187360 )

• E7.5 embryos exhibit a modest displacement of the anterior definitive endoderm towards the distal tip compared to wild-type embryos

abnormal anterior visceral endoderm morphology ( J:187360 )

• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with an expanded population throughout the visceral endoderm

abnormal distal visceral endoderm morphology ( J:187360 )

• E6.5 embryos exhibit aberrant distal visceral endoderm/anterior visceral endoderm localization, with an expanded population throughout the visceral endoderm

Genotype
MGI:7467523

cx4

• Allelic Composition: Pold1^tyrn/Pold1^tyrn; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

embryo

embryo phenotype ( J:327432 )

N • normal anterior-posterior (A-P) patterning in E8.5 embryos

N • normal anterior visceral endoderm positioning in E6.5 embryos

abnormal primitive streak elongation ( J:327432 )

• failure of primitive streak to extend to the distal tip in E7.5 embryos

• severe deficiency of allantois mesoderm in E7.5 embryos

• aberrantly positioned anterior definitive endoderm (ADE) and axial mesoderm (AME) in E7.5 embryos

abnormal allantois morphology ( J:327432 )

• severe deficiency of allantois mesoderm in E7.5 embryos

Genotype
MGI:5050122

cx5

• Allelic Composition: Rac1^tm2Tyb/Rac1^tm2Tyb; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: mixed

embryo

abnormal anterior visceral endoderm cell migration ( J:166095 )

• anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5

• between E5.5 and E5.75 some cells lose contact with the basement membrane

• at E6.5 cells that fail to migrate form a multilayered epithelium

cellular

abnormal anterior visceral endoderm cell migration ( J:166095 )

• anterior visceral endoderm cells fail to migrate from the distal tip to the embryonic-extraembryonic boundary by E6.5

• between E5.5 and E5.75 some cells lose contact with the basement membrane

• at E6.5 cells that fail to migrate form a multilayered epithelium