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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ern1tm2.1Rjk
targeted mutation 2.1, Randal J Kaufman
MGI:4949317
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ern1tm2.1Rjk/Ern1tm2.1Rjk Not Specified MGI:4949414
cn2
 		Ern1tm1Rjk/Ern1tm2.1Rjk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:4949418


Genotype
MGI:4949414
hm1
Allelic
Composition		 Ern1tm2.1Rjk/Ern1tm2.1Rjk
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm2.1Rjk mutation (0 available); any Ern1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171230 )
• mice are viable, fertile, and apparently normal




Genotype
MGI:4949418
cn2
Allelic
Composition		 Ern1tm1Rjk/Ern1tm2.1Rjk
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm1Rjk mutation (0 available); any Ern1 mutation (58 available)
Ern1tm2.1Rjk mutation (0 available); any Ern1 mutation (58 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte apoptosis ( J:171230 )
• 5-times in response to Bortezomib treatment
increased liver triglyceride level ( J:171230 )
• following tamoxifen treatment
• following partial hepatectomy
• in response to Bortezomib treatment
abnormal hepatocyte morphology ( J:171230 )
• liver cells exhibit less rough endoplasmic reticulum content compared with control liver cells
hepatic steatosis ( J:171230 )
• mice exhibit a slight increase in hepatic lipid content compared with control mice
• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice
• however, phospholipid synthesis is normal

homeostasis/metabolism
abnormal lipid level ( J:171230 )
• mice exhibit a slight increase in hepatic lipid content compared with control mice
• mice subjected to liver stress (partial hepatectomy or treatment with tamoxifen or Bortezomib) exhibit increased accumulation of lipids in the liver compared with control mice
• however, phospholipid levels in the liver are normal
decreased circulating cholesterol level ( J:171230 )
• following tamoxifen-treatment
increased liver triglyceride level ( J:171230 )
• following tamoxifen treatment
• following partial hepatectomy
• in response to Bortezomib treatment
abnormal apolipoprotein level ( J:171230 )
• following tamoxifen-treatment, secretion of apolipoproteins from liver cells is decreased compared to in control mice

cellular
increased hepatocyte apoptosis ( J:171230 )
• 5-times in response to Bortezomib treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory