Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-cre/ERT2)1Crm
• Allele Name: transgene insertion 1, Benoit de Crombrugghe
• Allele ID: MGI:4949435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nudt21^tm1.1Ejwpj/Nudt21^tm1.1Ejwpj Tg(Col1a1-cre/ERT2)1Crm/0	involves: C57BL/6J * CBA/J	MGI:6386380

Genotype
MGI:6386380

cn1

• Allelic Composition: Nudt21^tm1.1Ejwpj/Nudt21^tm1.1Ejwpj; Tg(Col1a1-cre/ERT2)1Crm/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased collagen level ( J:283035 )

• in the bronchial alveolar lavage fluid of bleomycin- and tamoxifen-treated mice once or repeatedly

increased susceptibility to injury ( J:283035 )

• bleomycin- and tamoxifen-treated mice exhibit increased collagen in bronchial alvealar lavage (BAL) fluid, alpha-SMA+ cells, total cell numbers (including macrophages and lymphocytes in the BAL), and exaggerated features of pulmonary fibrosis compared with wild-type mice

• however, late stage cellular inflammation and mortality are not affected

respiratory system

pulmonary fibrosis ( J:283035 )

• increased in bleomycin- and tamoxifen-treated mice once or repeatedly

immune system

increased acute inflammation ( J:283035 )

• in the early stages in the lungs of bleomycin- and tamoxifen-treated mice

• however, late stage cellular inflammation is not affected