Analysis Tools
mortality/aging
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• mice die at around 4 weeks after birth (between P25 and P27) when doxycycline (DOX) is removed the day following birth to allow activation of MET in postnatal cardiomyocytes
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cardiovascular system
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• mice show a massive progressive increase in cardiac hypertrophy from P21 to P27 when DOX is removed the day after birth
• hypertrophy is concentric as indicated by increase in the thickness/radius ratio, left ventricle mass, and left mass normalized to body weight
• treating mice with DOX at P21 rescues the cardiac hypertrophy phenotype
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• echocardiography shows reduced left ventricle volumes, in both diastole and systole, in mice when DOX is removed a day after birth
• however, mice do not show systolic dysfunction as assessed by ejection fraction at P27
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• mice die with signs of congestive heart failure including lung edema, alopecia, ascites, dyspnea, cyanosis, and lethargy following the removal of DOX the day after birth
• however, ejection fraction is preserved
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behavior/neurological
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
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• food intake is normal at P22 but decreases starting from P23 in mice in which DOX was removed the day after birth
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growth/size/body
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• mice show a massive progressive increase in cardiac hypertrophy from P21 to P27 when DOX is removed the day after birth
• hypertrophy is concentric as indicated by increase in the thickness/radius ratio, left ventricle mass, and left mass normalized to body weight
• treating mice with DOX at P21 rescues the cardiac hypertrophy phenotype
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• greater than 27% decrease in body weight at P27 in mice when DOX is removed the day after birth
• decrease in body weight results from a reduction in body weight gain starting from P20
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• mice in which DOX was removed the day after birth develop a cardiac cachexia syndrome characterized by weight loss and reduced weight gain, decreased food intake, and skeletal muscle wasting
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homeostasis/metabolism
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• mice treated with DOX at P21 show rescue of lung edema
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
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integument
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
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muscle
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• mice showing signs of congestive heart failure show wasted hindlimb muscles and have reduced skeletal muscle weight
• treating mice with DOX at P21 rescues the loss of muscular weight
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respiratory system
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
• mice treated with DOX at P21 show rescue of lung edema
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• one of the signs of congestive heart failure that develops in mice when DOX is removed the day after birth
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congestive heart failure | DOID:6000 | J:241276 | ||
