Phenotypes associated with this allele

• Allele Symbol: Gnrh1^tm1.1Hjn
• Allele Name: targeted mutation 1.1, Horacio J Novaira
• Allele ID: MGI:4949468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrh1^tm1.1Hjn/Gnrh1^tm1.1Hjn	involves: C57BL/6	MGI:4949470

Genotype
MGI:4949470

hm1

• Allelic Composition: Gnrh1^tm1.1Hjn/Gnrh1^tm1.1Hjn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

delayed vaginal opening ( J:170674 )

• delayed by about 6 days

delayed female fertility ( J:170674 )

• the first day of estrus is delayed to about 35 days of age compared to 30 days of age in wild-type mice, in both cases this is 2-3 days after vaginal opening

abnormal female reproductive system physiology ( J:170674 )

♀ • the interval between litters is highly irregular ranging from 18 to 42 days compared to an interval of between 20 and 25 days in wild-type mice

♀ • however, the number and size of litters produced in an 8 month span is similar to wild-type mice

abnormal ovary physiology ( J:170674 )

♀ • elevated levels of gonadotropin releasing hormone

short diestrus ( J:170674 )

♀ • shorter metestrus-diestrus phase

short metestrus ( J:170674 )

♀ • shorter metestrus-diestrus phase

short proestrus ( J:170674 )

♀

short estrous cycle ( J:170674 )

♀ • resulting from shorter proestrus and metestrus-diestrus phases with a normal duration of the estrus phase

homeostasis/metabolism

abnormal hormone level ( J:170674 )

• elevated levels of gonadotropin releasing hormone in the ovaries

increased circulating estradiol level ( J:170674 )

• increased levels during proestrus

increased circulating luteinizing hormone level ( J:170674 )

• increased levels during the luteinizing hormone surge in the proestrus phase of the estrus cycle

increased circulating progesterone level ( J:170674 )

• increased levels during proestrus

nervous system

nervous system phenotype ( J:170674 )

N • neuron numbers in the organum vasculosum of the lamina terminalis are apparently normal

endocrine/exocrine glands

abnormal ovary physiology ( J:170674 )

♀ • elevated levels of gonadotropin releasing hormone