Phenotypes associated with this allele

• Allele Symbol: Cacna1c^tm1Itl
• Allele Name: targeted mutation 1, inGenious Targeting Laboratory
• Allele ID: MGI:4949646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1c^tm1Itl/Cacna1c^tm1Itl	B6.129S6-Cacna1c^tm1Itl	MGI:4949655

Genotype
MGI:4949655

hm1

• Allelic Composition: Cacna1c^tm1Itl/Cacna1c^tm1Itl
• Genetic Background: B6.129S6-Cacna1c^tm1Itl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:171162 )

• mice die within hours of birth

• however, treatment with captopril and isradipine extends survival to P4

lethality throughout fetal growth and development, incomplete penetrance ( J:171162 )

• some mice die between E15 and birth

• treatment with cyclosporin A to rescue cardiac hypertrophy does not prevent lethality

• however, treatment with isradipine, tadalafil, isradipine and tadalafil, T3 or captopril and isradipine rescue lethality between E13 and E18

cardiovascular system

patent ductus arteriosus ( J:171162 )

increased myocardial fiber size ( J:171162 )

increased heart weight ( J:171162 )

• heart weight relative to body weight is increased compared to in wild-type mice

• however, treatment with the calcium channel antagonist isradipine, tadalafil, or cyclosporin A reduces heart weight

cardiac hypertrophy ( J:171162 )

heart right ventricle hypertrophy ( J:171162 )

• concentric hypertrophy

internal hemorrhage ( J:171162 )

• blood pools in the abdomen

abnormal myocardial fiber physiology ( J:171162 )

• myocytes exhibit reduced L-type calcium ion current compared with wild-type cells

congestive heart failure ( J:171162 )

nervous system

abnormal neuron physiology ( J:171157 )

• neurons exhibit a decrease in L-type barium current amplitude compared with wild-type neurons

• however, voltage dependence of activation of L-type barium currents is normal

muscle

increased myocardial fiber size ( J:171162 )

heart right ventricle hypertrophy ( J:171162 )

• concentric hypertrophy

cellular

patent ductus arteriosus ( J:171162 )

growth/size/body

increased heart weight ( J:171162 )

• heart weight relative to body weight is increased compared to in wild-type mice

• however, treatment with the calcium channel antagonist isradipine, tadalafil, or cyclosporin A reduces heart weight

cardiac hypertrophy ( J:171162 )

heart right ventricle hypertrophy ( J:171162 )

• concentric hypertrophy