Phenotypes associated with this allele

• Allele Symbol: Tnfrsf13c^tm2.1Mass
• Allele Name: targeted mutation 2.1, Marc Schmidt-Supprian
• Allele ID: MGI:4949656
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Mx1-cre)1Cgn/0 Tnfrsf13c^tm2.1Mass/Tnfrsf13c^tm2.1Mass	involves: C57BL/6 * CBA	MGI:4949664

Genotype
MGI:4949664

cn1

• Allelic Composition: Tg(Mx1-cre)1Cgn/0; Tnfrsf13c^tm2.1Mass/Tnfrsf13c^tm2.1Mass
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased immature B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC

increased pro-B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC

abnormal bone marrow cell morphology/development ( J:170519 )

• pIpC-treated mice exhibit less recirculating B cells compared to in similarly treated control mice

increased pre-B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC

abnormal bone marrow cell physiology ( J:170519 )

• pIpC-treated mice fail to exhibit age-related decline in B lineage precursors (pro-B, pre-B, and immature B cells) in the bone marrow compared to in control mice

immune system

increased immature B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC

increased pro-B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC

increased pre-B cell number ( J:170519 )

• in the bone marrow of old mice treated with pIpC