Phenotypes associated with this allele

• Allele Symbol: Ldb3^tm6.2Chen
• Allele Name: targeted mutation 6.2, Ju Chen
• Allele ID: MGI:4949672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ldb3^tm6.2Chen/Ldb3^tm6.2Chen	involves: 129/Sv * Black Swiss * C57BL/6 * SJL	MGI:4949679

Genotype
MGI:4949679

hm1

• Allelic Composition: Ldb3^tm6.2Chen/Ldb3^tm6.2Chen
• Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:170494 )

• mice exhibit adult mortality beginning at 16 months, with non surviving past 20 months

postnatal lethality, incomplete penetrance ( J:170494 )

• 28% of mice die prior to weaning, mostly in the first week after birth

cardiovascular system

abnormal heart morphology ( J:170494 )

• at 5 months, mice exhibit calcification within the heart unlike wild-type mice

increased heart weight ( J:170494 )

• at 9 months

increased heart left ventricle size ( J:170494 )

• at 9 months, mice exhibit increased left ventricular internal dimensions at end-diastole compared with wild-type mice

• following pressure overload, mice exhibit a greater increase in chamber wall dimensions and cardiac impairment compared with wild-type mice

increased heart left ventricle weight ( J:170494 )

• isoproterenol-treated mice exhibit increased left ventricle weight compared with similarly treated wild-type mice

decreased heart left ventricle posterior wall thickness ( J:170494 )

• at 16 months, mice exhibit decreased left ventricular posterior wall thickness at end-diastole compared with wild-type mice

increased heart right ventricle size ( J:170494 )

• at 9 months

cardiac fibrosis ( J:170494 )

• severe at 5 months

dilated cardiomyopathy ( J:170494 )

• beginning at 9 months

• dilated cardiomyopathy is preceded by inotropic and lusitrophic dysfunction

decreased cardiac muscle contractility ( J:170494 )

• at 16 months, mice exhibit reduced fractional shortening compared with wild-type mice

• following pressure overload, mice exhibit a greater increase in chamber wall dimensions and cardiac impairment compared with wild-type mice

• dobutamine-treated mice exhibit inotropic and lusitrophic contractile dysfunction compared with similarly treated wild-type mice

• however, cardiac function is normal at 5 months

increased response of heart to induced stress ( J:170494 )

• following pressure overload, mice exhibit a greater increase in chamber wall dimensions and cardiac impairment compared with wild-type mice

• isoproterenol-treated mice exhibit increased left ventricle weight compared with similarly treated wild-type mice

growth/size/body

increased heart weight ( J:170494 )

• at 9 months

decreased body size ( J:170494 )

• however, mice recover normal weight by 3 months of age

postnatal growth retardation ( J:170494 )

homeostasis/metabolism

increased response of heart to induced stress ( J:170494 )

• following pressure overload, mice exhibit a greater increase in chamber wall dimensions and cardiac impairment compared with wild-type mice

• isoproterenol-treated mice exhibit increased left ventricle weight compared with similarly treated wild-type mice

muscle

dilated cardiomyopathy ( J:170494 )

• beginning at 9 months

• dilated cardiomyopathy is preceded by inotropic and lusitrophic dysfunction

decreased cardiac muscle contractility ( J:170494 )

• at 16 months, mice exhibit reduced fractional shortening compared with wild-type mice

• following pressure overload, mice exhibit a greater increase in chamber wall dimensions and cardiac impairment compared with wild-type mice

• dobutamine-treated mice exhibit inotropic and lusitrophic contractile dysfunction compared with similarly treated wild-type mice

• however, cardiac function is normal at 5 months

abnormal Z line morphology ( J:170494 )

• cardiac muscles exhibit wider and disorganized Z lines compared to in wild-type mice