Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pikfyvetm1.1Ashi targeted mutation 1.1, Assia Shisheva MGI:4949700 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse embryonic fibroblasts transfected with a cre-expressing plasmid exhibit arrested DNA synthesis unlike in wild-type cells
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• mouse embryonic fibroblasts transfected with a cre-expressing plasmid exhibit arrested DNA synthesis unlike in wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• energy expenditure is normal
• fasting glucose at 6 months is normal
• young mice exhibit normolipidemia
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• at 10 weeks and to a greater extent at 6 months
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• at 8.5 months
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• at 8 to 10 weeks of age that persists as mice age
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• at 8 to 10 weeks of age that persists as mice age
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• when normalized to body weight
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• when normalized to body weight
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• increased in epididymal fat
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• likely due to increased energy intake
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• beginning at 10 to 11 weeks of age and continuing as mice age
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| N |
• despite metabolic defects, muscle fiber type is unaltered
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• reduced in insulin stimulated muscle cells with cell surface accumulation of Slc2a4 (GLUT4)
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• when normalized to body weight
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• increased in epididymal fat
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• reduced in insulin stimulated muscle cells with cell surface accumulation of Slc2a4 (GLUT4)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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