Analysis Tools|
Allele Symbol Allele Name Allele ID |
Shank3tm2Gfng targeted mutation 2, Guoping Feng MGI:4949738 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are incapable of completing pre-training tasks for the touchscreen pairwise discrimination test, showing a trend towards completing fewer trials in stage 1, significantly fewer trials is stage 2, and require more days to reach criterion in stage 3
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• mice show reduced activity in the open field
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hippocampal neurons exhibit fewer mushroom-like spines
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• hippocampal neurons exhibit a greater number of immature thin spines
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• marker analysis indicates a change in postsynaptic density architecture
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• pyramidal-like hippocampal neurons show reduced miniature excitatory postsynaptic currents (mEPSCs) frequency, without changes in mEPSC amplitude
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal learning and memory in a Morris water maze
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• mice exhibit less time exploring the open arms of an elevated plus maze compared with wild-type mice
• mice exhibit increased latency to crossing a bright area in a light-dark emergence test compared with wild-type mice
• however, mice exhibit normal thigmotaxis in an open field and time spent on either side of the box in the light-dark emergence test
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• resulting in skin lesions
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• mice prefer to interact with an empty cage rather than a social partner unlike wild-type mice
• mice spend less time interacting with a social partner than wild-type mice
• mice fail to spend more time with a novel social partner unlike wild-type mice
• social withdrawal is not alleviated by cross fostering pups with wild-type dams
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• mice occasionally exhibit handling-induced seizures unlike wild-type mice
• however, no spontaneous seizures are observed
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• mice occasionally exhibit handling-induced seizures unlike wild-type mice
• however, no spontaneous seizures are observed
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• mice exhibit striatal hypertrophy compared with wild-type mice
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• medium spiny neurons exhibit neuronal hypertrophy with increased complexity of dendritic arborization, total dendritic length, and surface area compared to in wild-type mice
• spine density is reduced compared to in wild-type mice
• the neck width of medium spiny neuron spines is slightly larger than in wild-type mice
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• mice exhibit abnormal post-synaptic density composition compared to in wild-type mice
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• reduced frequency and peak amplitude in medium spiny neurons
• however, miniature excitatory postsynaptic current frequency and amplitude in the hippocampal CA1 sub-region are normal
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• at 3 to 6 months of age, mice exhibit pronounced skin lesions with varying degrees of penetrance due to excessive self-grooming unlike wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:171113 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the touchscreen pairwise discrimination task, mice are slower to reach criterion and exhibit trends toward making more errors (first trial errors) and more correction errors than wild-type mice
• however, mice exhibit normal open field activity and sociability in the three chamber test
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:243083 | ||
| Phelan-McDermid syndrome | DOID:0080354 |
OMIM:606232 |
J:243083 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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