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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pglyrp1tm1.1Lky
targeted mutation 1.1, Richard M Locksley
MGI:4949894
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pglyrp1tm1.1Lky/Pglyrp1tm1.1Lky B6.129S4-Pglyrp1tm1.1Lky MGI:4950041


Genotype
MGI:4950041
hm1
Allelic
Composition		 Pglyrp1tm1.1Lky/Pglyrp1tm1.1Lky
Genetic
Background		 B6.129S4-Pglyrp1tm1.1Lky
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pglyrp1tm1.1Lky mutation (1 available); any Pglyrp1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:171412 )
• neutrophils exhibit defective intracellular killing and digestion of relatively nonpathogenic gram-positive bacteria compared with wild-type cells
• however, neutrophil phagocytic uptake is normal
increased susceptibility to bacterial infection ( J:171412 )
• following intraperitoneal infection with gram-positive bacteria of low pathogenicity
• however, susceptibility to infection with more pathogenic gram-positive or gram-negative bacteria is normal

hematopoietic system
abnormal neutrophil physiology ( J:171412 )
• neutrophils exhibit defective intracellular killing and digestion of relatively nonpathogenic gram-positive bacteria compared with wild-type cells
• however, neutrophil phagocytic uptake is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory