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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgra2tm1.1Bstc
targeted mutation 1.1, Brad St Croix
MGI:4949901
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adgra2tm1.1Bstc/Adgra2tm1.2Bstc
Tg(Tek-cre)12Flv/0 		B6.Cg-Adgra2tm1.1Bstc/Adgra2tm1.2Bstc Tg(Tek-cre)12Flv MGI:4949906


Genotype
MGI:4949906
cn1
Allelic
Composition		 Adgra2tm1.1Bstc/Adgra2tm1.2Bstc
Tg(Tek-cre)12Flv/0
Genetic
Background		 B6.Cg-Adgra2tm1.1Bstc/Adgra2tm1.2Bstc Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1.1Bstc mutation (1 available); any Adgra2 mutation (43 available)
Adgra2tm1.2Bstc mutation (0 available); any Adgra2 mutation (43 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:171226 )
• at E12.5 glomeruloid bodies form in the lateral ventricle wall in the region adjacent to the ganglionic eminence, similar to what is seen in Gpr124tm1.2Bstc homozygotes

nervous system
abnormal brain vasculature morphology ( J:171226 )
• at E12.5 glomeruloid bodies form in the lateral ventricle wall in the region adjacent to the ganglionic eminence, similar to what is seen in Gpr124tm1.2Bstc homozygotes
abnormal telencephalon development ( J:171226 )
• failure of neocortex development
abnormal pallium development ( J:171226 )
• notably thinner at E15.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory