Phenotypes associated with this allele

• Allele Symbol: Otop1^tm1Dor
• Allele Name: targeted mutation 1, David M Ornitz
• Allele ID: MGI:4950042
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otop1^tm1Dor/Otop1^tm1Dor	Not Specified	MGI:4950378

Genotype
MGI:4950378

hm1

• Allelic Composition: Otop1^tm1Dor/Otop1^tm1Dor
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:171566 )

N • mice exhibit normal sensory epithelium of the utricle and saccule

absent otoliths ( J:171566 )

abnormal vestibular system physiology ( J:171566 )

• mice exhibit impaired swimming due to vestibular dysfunction compared with wild-type mice

• dissociated macular cultures from utricles exhibit abnormal purinergic response compared with wild-type cultures

behavior/neurological

impaired swimming ( J:171566 )

• due to vestibular dysfunction