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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnasas1tm1.1Jop
targeted mutation 1.1, Jo Peters
MGI:4950057
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gnasas1tm1.1Jop/Gnasas1+ involves: 129S1/Sv * M. spretus MGI:4950265
ht2
Gnasas1tm1.1Jop/Gnasas1+ involves: 129S/SvEv * 129S1/Sv MGI:4950263
ht3
Gnasas1tm1Jop/Gnasas1tm1.1Jop involves: 129S/SvEv * 129S1/Sv MGI:4950266


Genotype
MGI:4950265
ht1
Allelic
Composition
Gnasas1tm1.1Jop/Gnasas1+
Genetic
Background
involves: 129S1/Sv * M. spretus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Genotype
MGI:4950263
ht2
Allelic
Composition
Gnasas1tm1.1Jop/Gnasas1+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• when this allele is inherited paternally, mice exhibit hypomethylation of the Nesp (Gnas) somatic differentially methylated region (DMR) compared with wild-type mice
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Genotype
MGI:4950266
ht3
Allelic
Composition
Gnasas1tm1Jop/Gnasas1tm1.1Jop
Genetic
Background
involves: 129S/SvEv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
Gnasas1tm1Jop mutation (0 available); any Gnasas1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory