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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnasas1tm1.1Jop
targeted mutation 1.1, Jo Peters
MGI:4950057
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gnasas1tm1.1Jop/Gnasas1+ involves: 129S1/Sv * M. spretus MGI:4950265
ht2
 		Gnasas1tm1.1Jop/Gnasas1+ involves: 129S/SvEv * 129S1/Sv MGI:4950263
ht3
 		Gnasas1tm1Jop/Gnasas1tm1.1Jop involves: 129S/SvEv * 129S1/Sv MGI:4950266


Genotype
MGI:4950265
ht1
Allelic
Composition		 Gnasas1tm1.1Jop/Gnasas1+
Genetic
Background		 involves: 129S1/Sv * M. spretus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:171195 )
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Genotype
MGI:4950263
ht2
Allelic
Composition		 Gnasas1tm1.1Jop/Gnasas1+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:171195 )
• when this allele is inherited paternally, mice exhibit hypomethylation of the Nesp (Gnas) somatic differentially methylated region (DMR) compared with wild-type mice
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Genotype
MGI:4950266
ht3
Allelic
Composition		 Gnasas1tm1Jop/Gnasas1tm1.1Jop
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
Gnasas1tm1Jop mutation (0 available); any Gnasas1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:171195 )
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory