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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnas/Nespastm1.1Jop
targeted mutation 1.1, Jo Peters
MGI:4950063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gnas/Nespastm1.1Jop/Gnas+ involves: 129S1/Sv * M. spretus MGI:4950264
ht2
 		Gnas/Nespastm1.1Jop/Gnas+ involves: 129S/SvEv * 129S1/Sv MGI:4950262


Genotype
MGI:4950264
ht1
Allelic
Composition		 Gnas/Nespastm1.1Jop/Gnas+
Genetic
Background		 involves: 129S1/Sv * M. spretus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas/Nespastm1.1Jop mutation (0 available); any Gnas mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:171195 )
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




Genotype
MGI:4950262
ht2
Allelic
Composition		 Gnas/Nespastm1.1Jop/Gnas+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnas/Nespastm1.1Jop mutation (0 available); any Gnas mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:171195 )
• when this allele is inherited paternally, mice exhibit hypomethylation of the Nesp (Gnas) somatic differentially methylated region (DMR) compared with wild-type mice
• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory