Phenotypes associated with this allele

• Allele Symbol: Ighm^tm1.1Aak
• Allele Name: targeted mutation 1.1, Ahmed Khamlichi
• Allele ID: MGI:4950361
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighm^tm1.1Aak/Ighm^tm1.1Aak	involves: 129S2/SvPas * C57BL/6	MGI:4950367

Genotype
MGI:4950367

hm1

• Allelic Composition: Ighm^tm1.1Aak/Ighm^tm1.1Aak
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:171251 )

N • no immunodeficiency

N • V(D)J recombination is apparently normal

abnormal class switch recombination ( J:171251 )

• VDJCmu transcript levels are decreased

• partial inhibition of transcriptional elongation

• class switching to downstream isotypes (IgG1, IgG3, IgA) is mildly reduced

increased pro-B cell number ( J:171251 )

• slight increase in pro-B cells (B220+ IgM- Cd43^high)

decreased B cell number ( J:171251 )

• B220+ bone marrow population reduced 2.5 fold

decreased pre-B cell number ( J:171251 )

• slight decrease in pre-B cells (B220+ IgM- Cd43^low)

hematopoietic system

abnormal class switch recombination ( J:171251 )

• VDJCmu transcript levels are decreased

• partial inhibition of transcriptional elongation

• class switching to downstream isotypes (IgG1, IgG3, IgA) is mildly reduced

increased pro-B cell number ( J:171251 )

• slight increase in pro-B cells (B220+ IgM- Cd43^high)

decreased B cell number ( J:171251 )

• B220+ bone marrow population reduced 2.5 fold

decreased pre-B cell number ( J:171251 )

• slight decrease in pre-B cells (B220+ IgM- Cd43^low)