Analysis Tools
mortality/aging
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• most mice die between E11.5 and weaning
• however, over-expression of Flrt3 partially rescues lethality
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• fewer than expected mice are present throughout fetal growth and development
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• fewer than expected mice are present at weaning
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• some mice die between E11.5 and E12.5
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cardiovascular system
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• significant reduction in the thickness of the compact ventricular myocardium at E11.5
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• the epicardium is ruffled and uneven with numerous discontinuities disrupting cell-cell contracts unlike in wild-type mice
• the epicardial layer exhibits Perlecan depositions and an increase in thickness of the basement membrane layer compared to in wild-type mice
• however, over-expression of Flrt3 rescued epicardial integrity defects
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• significant reduction in the thickness of the endocardium lining the inner surface of the heart at E11.5
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• at E11.5 and E12.5
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hemorrhage
(
J:171515
)
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• at E11.5 and E12.5, mice exhibit blood pooling and superficial hemorrhaging unlike wild-type mice
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embryo
| N |
• mice exhibit normal placenta
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homeostasis/metabolism
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• at E11.5 and E12.5
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muscle
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• significant reduction in the thickness of the compact ventricular myocardium at E11.5
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