nervous system
• disruption of somatic innervation during development in the absence of NMDARs at P14
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Allele Symbol Allele Name Allele ID |
Grin1tm2.1Stl targeted mutation 2.1, Susumu Tonegawa MGI:4950588 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• disruption of somatic innervation during development in the absence of NMDARs at P14
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
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• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
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• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
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• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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