nervous system
• disruption of somatic innervation during development in the absence of NMDARs at P14
|
Allele Symbol Allele Name Allele ID |
Grin1tm2.1Stl targeted mutation 2.1, Susumu Tonegawa MGI:4950588 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• disruption of somatic innervation during development in the absence of NMDARs at P14
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
|
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
|
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
|
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|