All Phenotypes Dazap1<tm1Pyen> MGI Mouse

premature death ( J:171493 )

• some males live more than one year

• a very small number of females live up to but not beyond 4 months of age

lethality during fetal growth through weaning, incomplete penetrance ( J:171493 )

• reduced numbers of homozygotes found at 2 weeks of age

• some deaths occur in the first days of life

• homozygotes are under represented at E19.5

• homozygotes are present in normal numbers at E13.5/E14.5 although MEFs purified from them grow poorly

decreased body size ( J:171493 )

• small in size at 4 days of age

• males surviving to adulthood have normal sized organs except for smaller than normal testes

abnormal reproductive system morphology ( J:171493 )

multinucleated giant male germ cells ( J:171493 )

abnormal ovary morphology ( J:171493 )

decreased mature ovarian follicle number ( J:171493 )

small ovary ( J:171493 )

abnormal testis morphology ( J:171493 )

small seminiferous tubules ( J:171493 )

• smaller in diameter

• atrophic

• few lumina are found at 16 days of age

• multinucleated giant cells and apoptotic germ cells present

small testis ( J:171493 )

• testes 40% of normal size

• seminal vesicles are of normal size

abnormal spermatogenesis ( J:171493 )

• begins but arrests with pachytene/diplotene spermatocytes at 25 days of age

abnormal spermatocyte morphology ( J:171493 )

• present in large numbers but no meiotic or post meiotic cells

• accumulation of post pachynema spermatocytes (72% of all spermatocytes as compared to 38% in controls)

abnormal spermatogonia proliferation ( J:171493 )

• present in large numbers

arrest of spermatogenesis ( J:171493 )

abnormal epididymis morphology ( J:171493 )

• lack sperm

abnormal reproductive system physiology ( J:171493 )

abnormal pregnancy ( J:171493 )

• unable to sustain pregnancy

• oogenesis is normal

male infertility ( J:171493 )