Phenotypes associated with this allele

• Allele Symbol: Dync1li1^m1Emcf
• Allele Name: mutation 1, Elizabeth M C Fisher
• Allele ID: MGI:4950685
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dync1li1^m1Emcf/Dync1li1^m1Emcf	involves: BALB/cAnNCrl * C3H/HeH * C57BL/6	MGI:4950695

Genotype
MGI:4950695

hm1

• Allelic Composition: Dync1li1^m1Emcf/Dync1li1^m1Emcf
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeH * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:171267 )

N • mice exhibit normal performance on a rotarod, spatial working memory, and reference memory acquisition and reversal

decreased exploration in new environment ( J:171267 )

increased anxiety-related response ( J:171267 )

• in an elevated plus maze, mice exhibit longer latency to enter open arm, enter open arms less, spend less time in open arm, and spend more time in the closed arms compared with wild-type mice

• in an elevated plus maze, mice exhibit increased defecation compared with wild-type mice

• in a successive alleys task, mice are slower to move into the more anxiogenic second alley, spend less time in the second alley, and enter the second alley compared with wild-type mice

increased grip strength ( J:171267 )

• slightly

abnormal gait ( J:171267 )

• the ratio of forepaw base of support to hindpaw base of support is reduced compared to in wild-type mice

nervous system

nervous system phenotype ( J:171267 )

N • nerve conduction velocity is normal

N • saphenous nerves exhibit average fiber size, fiber size distribution, g-ratio, or average axonal diameter

abnormal neuronal migration ( J:171267 )

• prefrontal cortex neurons migrate past their appropriate layer II/III position and into the uppermost part of the cortex and adopt abnormal orientation unlike in wild-type mice

abnormal dendrite morphology ( J:171267 )

• cortical neurons exhibit increased mean dendritic tree length with termination further from the soma compared to in wild-type mice

• prior to and following sciatic nerve crush, cultured neurons exhibit a greater number of branches than similarly treated wild-type neurons

abnormal action potential ( J:171267 )

• mice exhibit reduced peak-to-peak amplitude of A-fiber compound action potential in the saphenous nerve compared with wild-type mice

cellular

abnormal neuronal migration ( J:171267 )

• prefrontal cortex neurons migrate past their appropriate layer II/III position and into the uppermost part of the cortex and adopt abnormal orientation unlike in wild-type mice

abnormal lysosome physiology ( J:171267 )

• mouse embryonic fibroblasts exhibit slower rates of lysosome trafficking for degradation compared with wild-type cells

digestive/alimentary system

increased defecation amount ( J:171267 )

• in an elevated plus maze