Phenotypes associated with this allele

• Allele Symbol: Ppargc1a^tm1.1Amos
• Allele Name: targeted mutation 1.1, Antonio Moschetta
• Allele ID: MGI:4950745
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppargc1a^tm1.1Amos/Ppargc1a^tm1.1Amos	involves: C57BL/6JOlaHsd	MGI:4950748

Genotype
MGI:4950748

hm1

• Allelic Composition: Ppargc1a^tm1.1Amos/Ppargc1a^tm1.1Amos
• Genetic Background: involves: C57BL/6JOlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:171361 )

• villi and crypts are longer than in controls

abnormal small intestinal villus morphology ( J:171361 )

• villi and crypts are longer than in controls

neoplasm

increased incidence of tumors by chemical induction ( J:171361 )

• significantly increased numbers of intestinal tumors are induced by azoxymethane and dextran sodium sulfate than in controls

• chemically induced tumors are larger (10mm³) than in controls (2mm³)

increased tumor growth/size ( J:171361 )

• significantly increased numbers of intestinal tumors are induced by azoxymethane and dextran sodium sulfate than in controls

• chemically induced tumors are larger (10mm³) than in controls (2mm³)

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:171361 )

• villi and crypts are longer than in controls

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:171361 )

• significantly increased numbers of intestinal tumors are induced by azoxymethane and dextran sodium sulfate than in controls

• chemically induced tumors are larger (10mm³) than in controls (2mm³)