Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ppp2catm1.1Nju targeted mutation 1.1, Model Animal Research Center of Nanjing University MGI:4950915 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a further loss of mice is seen between E12.5 and E14.5
• however, some mice survive to adulthood
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• the expected number of mice are found at E10.5 but fewer than expected are found at E12.5
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• fetal livers contain very few erythrocytes but numbers of other hematopoietic lineage cells are similar to controls at E12.5
• severe impairment in the differentiation of proerythroblasts into erythroblasts in the fetal liver at E14.5
• total numbers of BFU-E and CFU-E are dramatically lower in fetal livers compared to controls
• however, embryonic erythropoiesis is similar to controls
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• severe in embryos
• however, surviving adults have normal steady-state hematocrit
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• dramatic reduction in the number of erythrocytes in the fetal liver at E14.5
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• increase in the number of LSK cells in the fetal liver at E14.5
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• cultured erythroid cells are more sensitive to apoptotic stimulation compared to control cells
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• enlarged fetal liver cells and reduced total liver cellularity at E12.5 and E14.5
• livers contain very few hematopoietic cells unlike in controls at E12.5
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• at E12.5
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| N |
• despite recombination in endothelial cells, no obvious vascular defects are detected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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