All Phenotypes Ehd3<tm1.2Haba> MGI Mouse

premature death ( J:171715 )

• mice die between 3 and 24 weeks of age

abnormal kidney vasculature morphology ( J:171715 )

• mice exhibit thrombotic microangiopathy (TMA)-like glomerular lesions unlike wild-type mice; however, no thrombi are observed

increased renal glomerulus apoptosis ( J:171715 )

• glomeruli exhibit increased apoptosis compared to in wild-type mice

increased urine protein level ( J:171715 )

• severe

podocyte foot process effacement ( J:171715 )

• mice exhibit podocytes with variable segmental foot process effacement

abnormal renal glomerulus basement membrane morphology ( J:171715 )

• mice display thickening and duplication of the GBM

• mice exhibit lamellation of the GBM

increased renal glomerulus basement membrane thickness ( J:171715 )

• mice display a thickened GBM

abnormal renal glomerulus morphology ( J:171715 )

• mice exhibit avascular glomeruli and widening of subendothelial zones containing "flocculent material"

abnormal glomerular capillary morphology ( J:171715 )

• mice exhibit abnormal capillary loops and platelet aggregation within capillary lumens unlike in wild-type mice

abnormal glomerular capillary endothelium morphology ( J:171715 )

• mice exhibit swollen glomerular endothelial cells

• many glomerular endothelial cells contain numerous small structures that resemble abnormal endosomes or vacuoles

absent glomerular endothelium fenestra ( J:171715 )

• mice exhibit a swollen endothelium without fenestrations

mesangial cell interposition ( J:171715 )

• mice exhibit variable degrees of mesangial cell interposition

expanded mesangial matrix ( J:171715 )

• mice exhibit an expanded mesangium

mesangiolysis ( J:171715 )

• mice exhibit vacuolation within a lytic-appearing mesangium

renal glomerulus hypertrophy ( J:171715 )

• mice exhibit enlarged glomeruli with segmental thickening

small kidney ( J:171715 )

decreased kidney weight ( J:171715 )

abnormal proximal convoluted tubule morphology ( J:171715 )

• mice exhibit protein reabsorption droplets in proximal tubules

dilated renal tubule ( J:171715 )

• some tubular dilation is observed

pale kidney ( J:171715 )