Phenotypes associated with this allele

• Allele Symbol: Cep55^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4951017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep55^tm1a(EUCOMM)Hmgu/Cep55^tm1a(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6458514

Genotype
MGI:6458514

hm1

• Allelic Composition: Cep55^{tm1a(EUCOMM)Hmgu}/Cep55^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:287102 )

• from P1 to P14, mice are cannibalized by parents with few survivors with only 3 of 74 mice alive at P14

nervous system

increased neuron apoptosis ( J:287102 )

• of neural progenitor cells at E16.5 in the subventricular zone, intermediate zone and cortical plate

decreased brain size ( J:287102 )

• at E18.5

decreased brain weight ( J:287102 )

• at E18.5

abnormal cerebral cortex morphology ( J:287102 )

• decreased length, thickness, and cellularity during embryonic development and at birth

decreased cerebral cortex cell density ( J:287102 )

thin cerebral cortex ( J:287102 )

• thinner and more transparent than control cortices

decreased neuronal precursor cell number ( J:287102 )

• of neural progenitor cells at E16.5 in the subventricular zone, intermediate zone and cortical plate

renal/urinary system

abnormal kidney cortex morphology ( J:287102 )

• thin with glomeruli in the superficial cortex in rare surviving mice at P14

abnormal renal glomerulus morphology ( J:287102 )

• small and hypercellular

cellular

increased cell nucleus count ( J:287102 )

• binucleated cells in the cortex and a slight increase in binucleated cells in tail tip fibroblast

abnormal mitotic cytokinesis ( J:287102 )

• neural progenitor cells exhibit impaired cytokinesis compared to in control cells

increased neuron apoptosis ( J:287102 )

• of neural progenitor cells at E16.5 in the subventricular zone, intermediate zone and cortical plate

behavior/neurological

absent gastric milk in neonates ( J:287102 )

abnormal motor capabilities/coordination/movement ( J:287102 )

• severe impairment

craniofacial

abnormal cranium morphology ( J:287102 )

• flat skull in newborn mice

growth/size/body

decreased body weight ( J:287102 )

• at E18.5 and P0

microcephaly ( J:287102 )

• at E18.5

integument

pallor ( J:287102 )

• at E18.5

skeleton

abnormal cranium morphology ( J:287102 )

• flat skull in newborn mice