Phenotypes associated with this allele

• Allele Symbol: Spink2^{Gt(327A6)Cmhd}
• Allele Name: gene trap 327A6, Centre for Modeling Human Disease
• Allele ID: MGI:4966113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spink2^Gt(327A6)Cmhd/Spink2^Gt(327A6)Cmhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5292056

Genotype
MGI:5292056

hm1

• Allelic Composition: Spink2^{Gt(327A6)Cmhd}/Spink2^{Gt(327A6)Cmhd}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Degeneration of germ cells in Spink2^{Gt(327A6)Cmhd}/Spink2^{Gt(327A6)Cmhd} seminferous tubules

reproductive system

reproductive system phenotype ( J:175913 )

N • female fertility is normal

oligozoospermia ( J:175913 )

♂

teratozoospermia ( J:175913 )

♂ • with vacuolization

kinked sperm flagellum ( J:175913 )

♂ • bending at the principal and middle piece junction

abnormal male germ cell apoptosis ( J:175913 )

♂

abnormal seminiferous tubule morphology ( J:175913 )

♂

small seminiferous tubules ( J:175913 )

♂

small testis ( J:175913 )

♂

decreased testis weight ( J:175913 )

♂

decreased litter size ( J:175913 )

• from male mice

reduced male fertility ( J:175913 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:175913 )

♂

small seminiferous tubules ( J:175913 )

♂

small testis ( J:175913 )

♂

decreased testis weight ( J:175913 )

♂

cellular

oligozoospermia ( J:175913 )

♂

teratozoospermia ( J:175913 )

♂ • with vacuolization

kinked sperm flagellum ( J:175913 )

♂ • bending at the principal and middle piece junction

abnormal male germ cell apoptosis ( J:175913 )

♂