Phenotypes associated with this allele

• Allele Symbol: Trim27^{Gt(345D11)Cmhd}
• Allele Name: gene trap 345D11, Centre for Modeling Human Disease
• Allele ID: MGI:4966301
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim27^Gt(345D11)Cmhd/Trim27^Gt(345D11)Cmhd	B6.129-Trim27^Gt(345D11)Cmhd	MGI:5309138

Genotype
MGI:5309138

hm1

• Allelic Composition: Trim27^{Gt(345D11)Cmhd}/Trim27^{Gt(345D11)Cmhd}
• Genetic Background: B6.129-Trim27^{Gt(345D11)Cmhd}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:180433 )

N • T and B cell development is normal

abnormal T-helper 1 physiology ( J:180433 )

• Th1 and Th2 CD4 T cells exhibit increased potassium/calcium channel activity (2-fold) and TCR-stimulated calcium influx compared with wild-type cells

abnormal T-helper 2 physiology ( J:180433 )

• Th1 and Th2 CD4 T cells exhibit increased potassium/calcium channel activity (2-fold) and TCR-stimulated calcium influx compared with wild-type cells

increased interferon-gamma secretion ( J:180433 )

• in Th0 CD4 T cells treated with superantigen staphylococcal enterotoxin E

increased tumor necrosis factor secretion ( J:180433 )

• in Th0 CD4 T cells treated with superantigen staphylococcal enterotoxin E

hematopoietic system

abnormal T-helper 1 physiology ( J:180433 )

• Th1 and Th2 CD4 T cells exhibit increased potassium/calcium channel activity (2-fold) and TCR-stimulated calcium influx compared with wild-type cells

abnormal T-helper 2 physiology ( J:180433 )

• Th1 and Th2 CD4 T cells exhibit increased potassium/calcium channel activity (2-fold) and TCR-stimulated calcium influx compared with wild-type cells