Analysis Tools
behavior/neurological
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• no evidence of myoclonus or limb dystonia is seen from the early postnatal period through 1.5 years of age when the allele is paternally inherited
• myoclonus is not seen in response to audiogenic or tactile stimuli
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• preweaning mice exhibit occasional stimulus-induced appendicular flexion posturing when the allele is inherited paternally
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• males and females exhibit lower scores on the cross-maze test when the allele is inherited paternally
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• mice show more slips on the 9-mm round beam and the 9-mm square beam than wild-type mice when the allele is inherited paternally
• however, mice show normal behavior on the rotarod
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• preweaning mice exhibit tiptoe walking when the allele is inherited paternally
• males and females with the paternally inherited allele exhibit higher scores on the rating scale for abnormal movements
• males exhibit higher forepaw and hindpaw stride frequencies when the allele is inherited paternally
• hindpaw stance width is narrower when the allele is inherited paternally
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• males exhibit shorter forepaw and hindpaw stride lengths when the allele is inherited paternally
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• mice are less active on multiple parameters of the open-field activity when the allele is inherited paternally, with females showing a greater decrease in activity than males
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growth/size/body
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• mice at 10-15% smaller when the allele is inherited paternally
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homeostasis/metabolism
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• noradrenaline levels trend higher when the allele is inherited paternally
• however, monoamine levels are normal
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