Phenotypes associated with this allele

• Allele Symbol: Xpnpep1^{Gt(S22-1B1)Sor}
• Allele Name: gene trap S22-1B1, Philippe Soriano
• Allele ID: MGI:4973607
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xpnpep1^Gt(S22-1B1)Sor/Xpnpep1^Gt(S22-1B1)Sor	B6.129S4-Xpnpep1^Gt(S22-1B1)Sor	MGI:5495163
hm2	Xpnpep1^Gt(S22-1B1)Sor/Xpnpep1^Gt(S22-1B1)Sor	involves: 129S4/SvJae * C57BL/6J	MGI:5495164

Genotype
MGI:5495163

hm1

• Allelic Composition: Xpnpep1^{Gt(S22-1B1)Sor}/Xpnpep1^{Gt(S22-1B1)Sor}
• Genetic Background: B6.129S4-Xpnpep1^{Gt(S22-1B1)Sor}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:193753 )

• mice do not survive beyond 3 days after birth

Genotype
MGI:5495164

hm2

• Allelic Composition: Xpnpep1^{Gt(S22-1B1)Sor}/Xpnpep1^{Gt(S22-1B1)Sor}
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

mortality/aging

abnormal survival ( J:193753 )

• male mice exhibit reduced survival compared with female mice

postnatal lethality, incomplete penetrance ( J:193753 )

prenatal lethality, incomplete penetrance ( J:193753 )

• fewer than expected mice are produced from heterozygotes

growth/size/body

decreased birth body size ( J:193753 )

microcephaly ( J:193753 )

decreased body size ( J:193753 )

decreased body weight ( J:193753 )

decreased body length ( J:193753 )

postnatal growth retardation ( J:193753 )

• in male and female mice without a difference between gender growth rates unlike in wild-type mice

nervous system

decreased brain size ( J:193753 )

forebrain hypoplasia ( J:193753 )

• reduced width, length and thickness

homeostasis/metabolism

abnormal urine color ( J:193753 )

• slightly dark urine

increased urine protein level ( J:193753 )

• peptiduria

renal/urinary system

abnormal urine color ( J:193753 )

• slightly dark urine

increased urine protein level ( J:193753 )

• peptiduria