Phenotypes associated with this allele

• Allele Symbol: Qtrt1^{Gt(S12-11A1)Sor}
• Allele Name: gene trap S12-11A1, Philippe Soriano
• Allele ID: MGI:4974232
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qtrt1^Gt(S12-11A1)Sor/Qtrt1^Gt(S12-11A1)Sor	involves: 129S4/SvJaeSor	MGI:5014762
ht2	Qtrt1^Gt(S12-11A1)Sor/Qtrt1^+	involves: 129S4/SvJaeSor	MGI:5014763

Genotype
MGI:5014762

hm1

• Allelic Composition: Qtrt1^{Gt(S12-11A1)Sor}/Qtrt1^{Gt(S12-11A1)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:173496 )

• levels of queuosine-modified tRNA (Q-tRNA) are reduced compared to in wild-type cells

• tyrosine production from phenylalanine is reduced compared to in wild-type cells

homeostasis/metabolism

decreased circulating tyrosine level ( J:173496 )

• following injection of phenylalanine, tyrosine plasma levels are reduced compared to in similarly treated wild-type mice

Genotype
MGI:5014763

ht2

• Allelic Composition: Qtrt1^{Gt(S12-11A1)Sor}/Qtrt1⁺
• Genetic Background: involves: 129S4/SvJaeSor

cellular

abnormal cell physiology ( J:173496 )

• levels of queuosine-modified tRNA (Q-tRNA) are reduced compared to in wild-type cells

• tyrosine production from phenylalanine is reduced compared to in wild-type cells

homeostasis/metabolism

decreased circulating tyrosine level ( J:173496 )

• following injection of phenylalanine, tyrosine plasma levels are reduced compared to in similarly treated wild-type mice