Phenotypes associated with this allele

• Allele Symbol: Nmral1^{Gt(S8-10A1)Sor}
• Allele Name: gene trap S8-10A1, Philippe Soriano
• Allele ID: MGI:4974651
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nmral1^Gt(S8-10A1)Sor/Nmral1^Gt(S8-10A1)Sor Tg(MMTV-PyVT)634Mul/0	B6.Cg-Nmral1^Gt(S8-10A1)Sor Tg(MMTV-PyVT)634Mul	MGI:6473979

Genotype
MGI:6473979

cx1

• Allelic Composition: Nmral1^{Gt(S8-10A1)Sor}/Nmral1^{Gt(S8-10A1)Sor}; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: B6.Cg-Nmral1^{Gt(S8-10A1)Sor} Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:282813 )

• at 150 days of age, mammary adenocarcinoma number is significantly lower than that in Tg(MMTV-PyVT)634Mul/0 mice and Nmral1^{Gt(S8-10A1)Sor}/Nmral1⁺ Tg(MMTV-PyVT)634Mul/0 mice

decreased tumor growth/size ( J:282813 )

• at 150 days of age, total mammary tumor weight is significantly lower than that in Tg(MMTV-PyVT)634Mul/0 mice and Nmral1^{Gt(S8-10A1)Sor}/Nmral1⁺ Tg(MMTV-PyVT)634Mul/0 mice

increased tumor latency ( J:282813 )

• mice show a significant delay in the development of mammary tumors with only about half (7/12) of mice developing tumors by 150 days of age, whereas all but one (17/18) of Tg(MMTV-PyVT)634Mul/0 mice and Nmral1^{Gt(S8-10A1)Sor}/Nmral1⁺ Tg(MMTV-PyVT)634Mul/0 mice spontaneously develop mammary tumors by 150 days of age

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:282813 )

• at 150 days of age, mammary adenocarcinoma number is significantly lower than that in Tg(MMTV-PyVT)634Mul/0 mice and Nmral1^{Gt(S8-10A1)Sor}/Nmral1⁺ Tg(MMTV-PyVT)634Mul/0 mice

integument

decreased mammary gland tumor incidence ( J:282813 )

• at 150 days of age, mammary adenocarcinoma number is significantly lower than that in Tg(MMTV-PyVT)634Mul/0 mice and Nmral1^{Gt(S8-10A1)Sor}/Nmral1⁺ Tg(MMTV-PyVT)634Mul/0 mice