Phenotypes associated with this allele

• Allele Symbol: Gdi2^{Gt(S1-11F1)Sor}
• Allele Name: gene trap S1-11F1, Philippe Soriano
• Allele ID: MGI:4974973
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdi2^Gt(S1-11F1)Sor/Gdi2^Gt(S1-11F1)Sor	B6.129S4-Gdi2^Gt(S1-11F1)Sor	MGI:7641390
ht2	Gdi2^Gt(S1-11F1)Sor/Gdi2^+	B6.129S4-Gdi2^Gt(S1-11F1)Sor	MGI:7641391

Genotype
MGI:7641390

hm1

• Allelic Composition: Gdi2^{Gt(S1-11F1)Sor}/Gdi2^{Gt(S1-11F1)Sor}
• Genetic Background: B6.129S4-Gdi2^{Gt(S1-11F1)Sor}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:326029 )

• embryonic lethality between E10.5 to E14.5, with no viable fetuses recovered after E14.5

embryo

increased embryonic tissue cell apoptosis ( J:326029 )

• embryos show extensive cell death and cell loss

• E12.5 livers shows increased apoptosis

embryonic growth retardation ( J:326029 )

• developmental retardation becomes apparent at E14.5

growth/size/body

embryonic growth retardation ( J:326029 )

• developmental retardation becomes apparent at E14.5

cellular

increased embryonic tissue cell apoptosis ( J:326029 )

• embryos show extensive cell death and cell loss

• E12.5 livers shows increased apoptosis

Genotype
MGI:7641391

ht2

• Allelic Composition: Gdi2^{Gt(S1-11F1)Sor}/Gdi2⁺
• Genetic Background: B6.129S4-Gdi2^{Gt(S1-11F1)Sor}

immune system

immune system phenotype ( J:326029 )

N • mice challenged with lipopolysaccharide (LPS) produce similar levels of cytokines following LPS stimulation as wild-type mice, with no difference is survival