Phenotypes associated with this allele

• Allele Symbol: Exoc4^{Gt(SABetageo4)Sor}
• Allele Name: gene trap SABetageo4, Philippe Soriano
• Allele ID: MGI:4975171
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exoc4^Gt(SABetageo4)Sor/Exoc4^Gt(SABetageo4)Sor	involves: 129S7/SvEvBrd	MGI:3037829

Genotype
MGI:3037829

hm1

• Allelic Composition: Exoc4^{Gt(SABetageo4)Sor}/Exoc4^{Gt(SABetageo4)Sor}
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:45340 )

• embryos in advanced stage of resorption by E10.5

embryo

abnormal mesoderm development ( J:45340 )

• no evidence of mesoderm cells at E7.5

delayed gastrulation ( J:45340 )

• initiation of gastrulation is about 1 day late

• homozygotes reach the advanced egg cylinder stage around E7.5

abnormal rostral-caudal axis patterning ( J:45340 )

• although anterior-posterior patterning is initiated, about 1 day late, no clearly defined axis exists at E8.5

decreased embryo size ( J:45340 )

• at E7.5, embryos were half normal size

decreased paraxial mesoderm size ( J:45340 )

• formation of paraxial mesoderm is deficient

absent amniotic cavity ( J:45340 )

• an amnionic cavity is not obvious at E7.5

small visceral yolk sac ( J:79478 )

• surrounded by a mass of necrotic cells

growth/size/body

decreased embryo size ( J:45340 )

• at E7.5, embryos were half normal size