Phenotypes associated with this allele

• Allele Symbol: Chat/Slc18a3^tm1Vpra
• Allele Name: targeted mutation 1, Vania Prado
• Allele ID: MGI:4999563
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chat/Slc18a3^tm1Vpra/Chat/Slc18a3^tm1Vpra	involves: 129S4/SvJae * C57BL/6J	MGI:4999574
ht2	Chat/Slc18a3^tm1Vpra/Chat/Slc18a3^tm1.1Vpra	involves: 129S4/SvJae * C57BL/6J	MGI:4999576

Genotype
MGI:4999574

hm1

• Allelic Composition: Chat/Slc18a3^tm1Vpra/Chat/Slc18a3^tm1Vpra
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:171696 )

N • mice exhibit normal grip force, wire-hanging, gait, and anxiety-related behaviors

hyperactivity ( J:171696 )

• intermediate compared with wild-type mice and Chat/Slc18a3^tm1Vpra/Chat/Slc18a3^tm1.1Vpra

nervous system

abnormal miniature endplate potential ( J:171696 )

• miniature endplate potential amplitude and frequency are increased compared to in wild-type mice

Genotype
MGI:4999576

ht2

• Allelic Composition: Chat/Slc18a3^tm1Vpra/Chat/Slc18a3^tm1.1Vpra
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:171696 )

N • mice exhibit normal grip force, wire-hanging, gait, and anxiety-related behaviors

hyperactivity ( J:171696 )

• compared with wild-type mice and Chat/Slc18a3^tm1Vpra homozygotes

increased vertical activity ( J:171696 )

nervous system

abnormal miniature endplate potential ( J:171696 )

• miniature endplate potential amplitude and frequency are increased compared to in wild-type mice