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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm4btm1.1Okad
targeted mutation 1.1, Hitoshi Okada
MGI:4999586
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm4btm1.1Okad/Kdm4btm1.1Okad involves: 129P2/OlaHsd MGI:4999587
cn2
 		Kdm4btm1.1Okad/Kdm4btm1.1Okad involves: 129P2/OlaHsd MGI:4999590
cn3
 		Kdm4btm1.1Okad/Kdm4btm1.1Okad
Tg(MMTV-cre)1Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4999589


Genotype
MGI:4999587
hm1
Allelic
Composition		 Kdm4btm1.1Okad/Kdm4btm1.1Okad
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4btm1.1Okad mutation (0 available); any Kdm4b mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171678 )
• mice are born in Mendelian ratio and display no abnormalities




Genotype
MGI:4999590
cn2
Allelic
Composition		 Kdm4btm1.1Okad/Kdm4btm1.1Okad
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4btm1.1Okad mutation (0 available); any Kdm4b mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:171678 )
• mammary gland epithelial cells exposed to a cre-expressing retrovirus exhibit decreased proliferation compared with control cells

integument
decreased mammary gland epithelial cell proliferation ( J:171678 )
• mammary gland epithelial cells exposed to a cre-expressing retrovirus exhibit decreased proliferation compared with control cells

cellular
decreased mammary gland epithelial cell proliferation ( J:171678 )
• mammary gland epithelial cells exposed to a cre-expressing retrovirus exhibit decreased proliferation compared with control cells




Genotype
MGI:4999589
cn3
Allelic
Composition		 Kdm4btm1.1Okad/Kdm4btm1.1Okad
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4btm1.1Okad mutation (0 available); any Kdm4b mutation (54 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Defective mammary gland development in Kdm4btm1.1Okad/Kdm4btm1.1Okad Tg(MMTV-cre)1Mam/0 mice

integument
abnormal mammary gland development ( J:171678 )
• mammary gland development is delayed with reduced branching compared to in wild-type mice
abnormal branching of the mammary ductal tree ( J:171678 )
• mammary gland branching is reduced compared to in wild-type mice

endocrine/exocrine glands
abnormal mammary gland development ( J:171678 )
• mammary gland development is delayed with reduced branching compared to in wild-type mice
abnormal branching of the mammary ductal tree ( J:171678 )
• mammary gland branching is reduced compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory