All Phenotypes Rassf9<Tg(PDLIM7*)2Cml> MGI Mouse

premature death ( J:171677 )

• no mice survive a year after weaning

postnatal lethality, incomplete penetrance ( J:171677 )

• fewer than expected mice survive to weaning

premature aging ( J:171677 )

• mice exhibit symptoms of premature aging (growth retardation, short lifespan, reduced subcutaneous adipose, and alopecia) compared wild-type mice

decreased subcutaneous adipose tissue amount ( J:171677 )

• with reduce adipose cellularity

abnormal keratinocyte differentiation ( J:171677 )

• keratinocytes exhibit abnormal initiation of differentiation and terminal differentiation compared with wild-type cells

alopecia ( J:171677 )

abnormal hair shaft morphology ( J:171677 )

• many hair follicles lack a hair shaft unlike in wild-type mice

abnormal skin adnexa physiology ( J:171677 )

• mice exhibit increased cell proliferation in the epidermal basal layer and outer root sheath (4-fold) but decreased hair bulb index compared with wild-type mice

abnormal hair cycle ( J:171677 )

abnormal hair cycle anagen phase ( J:171677 )

• mice exhibit fewer anagenic hair follicles than wild-type mice

dermal hyperplasia ( J:171677 )

thick dermal layer ( J:171677 )

• 1.7-fold

epidermal hyperplasia ( J:171677 )

thick epidermis ( J:171677 )

• 3-fold

abnormal skin physiology ( J:171677 )

• mice exhibit increased cell proliferation in the epidermal basal layer and outer root sheath (4-fold) but decreased hair bulb index compared with wild-type mice

increased keratinocyte proliferation ( J:171677 )

impaired skin barrier function ( J:171677 )

• moderate

abnormal lung saccule morphology ( J:171677 )

• saccule septation is stunted compared to in wild-type mice

overexpanded pulmonary alveolus ( J:171677 )