Analysis Tools
mortality/aging
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• fewer than expected mice are found at E15.5 to E16.5
• the number of mice found decreases from E15.5 to E18.5 and is lower than in another line of null mice (homozygous for Creb1tm2Gsc
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respiratory system
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• at E17.5 and E18.5, lung vasculature seems disorganized
• however, the vascular network is intact
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• at E17.5 and E18.5 lungs display little expansion of both the proximal and distal airways and have gross morphology comparable to E15.5?E16.5 lungs
• absence of round terminal saccular structures and the predominance of elongated tubules indicates an arrest or delay of normal lung development
|
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• defective alveolar epithelial cell (AEC) differentiation and lamellar body development
• differentiation of type II AECs is mildly impaired but differentiation of type I AECs is completely blocked
• the distal lung epithelium is almost entirely populated with undifferentiated progenitor cells at E17.5
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small lung
(
J:171712
)
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• at E17.5, proportional to the reduction in size of the whole body
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cardiovascular system
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• however, the vascular network is intact
• at E17.5 and E18.5, lung vasculature seems disorganized
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growth/size/body
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• at E17.5
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