Phenotypes associated with this allele

• Allele Symbol: Map3k11^m1J
• Allele Name: mutation 1 Jackson
• Allele ID: MGI:4999723
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k11^m1J/Map3k11^m1J	STOCK Map3k11^m1J/GrsrJ	MGI:5289986

Genotype
MGI:5289986

hm1

• Allelic Composition: Map3k11^m1J/Map3k11^m1J
• Genetic Background: STOCK Map3k11^m1J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Red dorsal lines in the skin of Map3k11^m1J/Map3k11^m1J pups (right and center) compared to control (left)

craniofacial

abnormal tooth morphology ( J:175214 )

• necrotic tooth pulp is reported at 4 weeks, 5 weeks, and 8.5 weeks, with infarcts of the pulp of the roots of the incisors, yet teeth from homozygotes surviving to later ages do not appear necrotic

abnormal dental pulp cavity morphology ( J:175214 )

abnormal tooth development ( J:175214 )

integument

abnormal epidermal layer morphology ( J:175214 )

abnormal skin appearance ( J:175214 )

• dorsal red stripes in the skin that run along the spine and from left to right across the crown of the head, across the base of the neck in front of the shoulders, and between the base of the ribs and the pelvis, and these stripes fade with age and are no longer evident by 3 weeks of age

mortality/aging

lethality at weaning, incomplete penetrance ( J:175214 )

• although a few homozygotes die just before or just after wean age, most homozygotes live a normal life span and are fertile

growth/size/body

abnormal tooth morphology ( J:175214 )

• necrotic tooth pulp is reported at 4 weeks, 5 weeks, and 8.5 weeks, with infarcts of the pulp of the roots of the incisors, yet teeth from homozygotes surviving to later ages do not appear necrotic

abnormal dental pulp cavity morphology ( J:175214 )

abnormal tooth development ( J:175214 )

skeleton

abnormal tooth morphology ( J:175214 )

• necrotic tooth pulp is reported at 4 weeks, 5 weeks, and 8.5 weeks, with infarcts of the pulp of the roots of the incisors, yet teeth from homozygotes surviving to later ages do not appear necrotic

abnormal dental pulp cavity morphology ( J:175214 )

abnormal tooth development ( J:175214 )