Phenotypes associated with this allele

• Allele Symbol: Hhex^tm1.1Tmj
• Allele Name: targeted mutation 1.1, Thomas M Jessell
• Allele ID: MGI:4999724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hhex^tm1.1Tmj/Hhex^+	involves: 129S1/Sv * FVB/N	MGI:4999726

Genotype
MGI:4999726

ht1

• Allelic Composition: Hhex^tm1.1Tmj/Hhex⁺
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Anterior visceral endoderm defects in Hhex^tm1.1Tmj/Hhex⁺ embryos

mortality/aging

abnormal survival ( J:171680 )

• half of expected mice die between E9.5 and weaning

• however, mice that survive to adulthood are normal

preweaning lethality, incomplete penetrance ( J:171680 )

• half of expected mice die between E9.5 and weaning

embryo

embryonic growth retardation ( J:171680 )

• 4.4% of mice are retarded at E6.5 and E7.5

abnormal egg cylinder morphology ( J:171680 )

• small and disorganized in 4.4% of mice at E6.5 and E7.5

decreased egg cylinder size ( J:171680 )

• small in 4.4% of mice at E6.5 and E7.5

abnormal primitive streak morphology ( J:171680 )

• mice exhibit impaired primitive streak patterning as determined by marker expression compared with wild-type mice

abnormal anterior visceral endoderm morphology ( J:171680 )

• mice exhibit reduced expression of anterior visceral endoderm markers compared with wild-type mice

nervous system

abnormal forebrain morphology ( J:171680 )

• at E8.5 and E9.5, forebrain patterning is abnormal compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:171680 )

• 4.4% of mice are retarded at E6.5 and E7.5