Allele Symbol Allele Name Allele ID |
Nek7tm1Mot targeted mutation 1, Benny Motro MGI:4999797 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only about 1% newborn are homozygous when heterozygous are crossed
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• most of homozygous newborns die within their first 2 weeks
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• homozygous newborns rarely survive up to 1 month
• Background Sensitivity: survival of homozygous mice in a mixed 129/ICR background survive longer then C57BL/6 or BALB/c background, however author did not show any data
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• homozygous mutant neonates weighed slightly less than their littermates at birth
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• after birth homozygous mouse shows a severe retardation in weight gain
• less than 50% of the weight of there wild type or heterozygous siblings at postnatal day 20
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• early passage of the MEF derived from E13.5 homozygous embryo exhibit increased binuclear phenotype
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• higher frequency of aneuploidy in homozygous embryo derived MEF
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• 4N tetraploidy cell population are elevated in homozygous embryo derived MEF
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• homozygous embryo derived MEF show disturbed frequency of primary cilia from multiple basal bodies
• do not exhibit metaphase arrest
• centrosome duplication is not affected
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• chromosomal counts of colcemid-arrested metaphase spreads of MEF derived from homozygous embryo shows increased chromosome content
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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