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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nek7tm1Mot
targeted mutation 1, Benny Motro
MGI:4999797
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nek7tm1Mot/Nek7tm1Mot involves: 129S1/Sv * 129X1/SvJ MGI:5306899
hm2
Nek7tm1Mot/Nek7tm1Mot involves: 129S1/Sv * 129X1/SvJ * BALB/c * ICR MGI:4999807


Genotype
MGI:5306899
hm1
Allelic
Composition
Nek7tm1Mot/Nek7tm1Mot
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek7tm1Mot mutation (0 available); any Nek7 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• absence of cataracts




Genotype
MGI:4999807
hm2
Allelic
Composition
Nek7tm1Mot/Nek7tm1Mot
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek7tm1Mot mutation (0 available); any Nek7 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only about 1% newborn are homozygous when heterozygous are crossed
• most of homozygous newborns die within their first 2 weeks
• homozygous newborns rarely survive up to 1 month
• Background Sensitivity: survival of homozygous mice in a mixed 129/ICR background survive longer then C57BL/6 or BALB/c background, however author did not show any data

growth/size/body
• homozygous mutant neonates weighed slightly less than their littermates at birth
• after birth homozygous mouse shows a severe retardation in weight gain
• less than 50% of the weight of there wild type or heterozygous siblings at postnatal day 20

cellular
• early passage of the MEF derived from E13.5 homozygous embryo exhibit increased binuclear phenotype
• higher frequency of aneuploidy in homozygous embryo derived MEF
• 4N tetraploidy cell population are elevated in homozygous embryo derived MEF
• homozygous embryo derived MEF show disturbed frequency of primary cilia from multiple basal bodies
• do not exhibit metaphase arrest
• centrosome duplication is not affected
• chromosomal counts of colcemid-arrested metaphase spreads of MEF derived from homozygous embryo shows increased chromosome content





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory